“This Easy Chicken Tetrazzini recipe is a creamy, comforting casserole made with tender fettuccine, shredded chicken, sautéed mushrooms, and a rich sour cream and cream of chicken soup sauce. Topped with Parmesan cheese and baked until bubbly, this delicious dish is perfect for family dinners, weeknight meals, or meal prepping. With its simple ingredients and easy preparation, this chicken tetrazzini recipe is a go-to comfort food everyone will love. Serve with a side salad or garlic bread for a complete meal. Make it ahead for convenience and enjoy leftovers the next day!”

Table of Contents

Ingredients

12 oz fettuccine
1 ½ tablespoons butter
2 ½ cups sliced mushrooms
2 ½ cups cooked and shredded chicken breast
1 can condensed cream of chicken soup
1 ½ cups sour cream
½ cup reserved pasta cooking water
Salt and pepper, to taste
2 tablespoons fresh parsley, chopped
⅓ cup grated Parmesan cheese

Instructions

Preheat the Oven: Preheat your oven to 350°F (175°C). Grease a 9×13-inch casserole dish and set it aside.
Cook the Pasta: Cook the fettuccine according to the package directions. Before draining, reserve ½ cup of the pasta cooking water for the sauce.
Sauté the Mushrooms: In a large skillet, melt the butter over medium heat. Add the sliced mushrooms and cook until they are tender and the water has evaporated, about 5-7 minutes.
Prepare the Sauce: In a large bowl, combine the cooked fettuccine, shredded chicken, sautéed mushrooms, cream of chicken soup, sour cream, reserved pasta water, fresh parsley, salt, and pepper. Stir to mix everything together.
Assemble and Bake: Pour the mixture into the prepared casserole dish and spread it out evenly. Sprinkle the grated Parmesan cheese over the top.
Bake: Place the casserole in the preheated oven and bake for about 30 minutes, or until the dish is hot and bubbly.
Serve: Remove from the oven, let cool for a few minutes, and serve. Enjoy!

Tips

Make-Ahead Option: You can assemble the casserole the night before and bake it the next day. Just add a few extra minutes to the baking time if baking from cold.
Extra Creaminess: If you prefer a creamier dish, you can add an additional ½ cup of sour cream or use a combination of cream cheese and sour cream.
Mushroom Alternatives: If you’re not a fan of mushrooms, you can substitute them with diced bell peppers or spinach for a different flavor.

Variations and Substitutions

Gluten-Free Version: Use gluten-free pasta to make this dish gluten-free.
Dairy-Free Option: Substitute sour cream with a dairy-free sour cream alternative and use dairy-free cheese.
Herb Variations: Try adding thyme, rosemary, or basil for a fresh, herby twist.

FAQs

Can I use a different type of pasta? Yes, you can substitute fettuccine with penne, rotini, or any other pasta shape.
Can I use leftover chicken? Yes, this is a great way to use up leftover chicken. Just shred it and mix it in with the sauce.
How do I store leftovers? Store leftovers in an airtight container in the fridge for up to 3 days. Reheat in the oven or microwave until warmed through.

Serving Suggestions

Serve with a side salad and garlic bread for a complete meal.
Pair with roasted vegetables or steamed broccoli for added nutrition.

Why You’ll Love This Recipe

This Easy Chicken Tetrazzini is the ultimate comfort food — creamy, cheesy, and packed with flavor. It’s quick to make, uses simple ingredients, and can be easily customized to your tastes. Perfect for busy weeknights or family gatherings, this dish is guaranteed to satisfy everyone’s cravings!